When choosing a papaya at the store, consider when and how you want to eat it. Green papayas are not ripe yet and will not have the characteristic flavor or texture. However, unripe papayas are used in some cooked dishes or raw in certain styles of salads. Papayas with red and orange skin are riper. You want it to be slightly soft to the touch, but not overly soft.
If you do buy unripened papayas, store them at room temperature to allow them to ripen before consuming.
Once you are ready to eat the papaya, simply cut it open, scoop out the seeds, and eat the orange interior. The skin and seeds are not poisonous, but most people do not eat them.